Current ODT research
ODT Research Registry
All active research studies registered with NHSBT ODT are included below. This indicates the allocation scheme ranking where relevant; the study title; location; the annual original request of organs; the number of organs received per study, and the study duration.
As of January 2018 there were 38 studies active on the ODT Research Registry, excluding three registered Research Tissue Banks. Three of the active studies aim to transplant organs into recipients.
Historically, UK Transplant (UKT) - now NHS Blood and Transplant (NHSBT) - supported a body of research focused primarily on the considerable expertise in clinical audit and development of models of selection, allocation and outcomes. This work, delivered primarily by what is now the Department of Statistics and Clinical Audit (which sits within the Clinical Directorate), was carried out in conjunction with the clinicians working through the Advisory Groups.
This work has attracted international acclaim and has had a considerable impact on the national and international reputation of NHSBT as well as directly contributing to better patient outcomes. On a smaller scale, Advisory Groups have worked to support clinical trials. The research done in Organ Donation and Transplantation (ODT) has been largely supported by research grants. The Directions for NHSBT require that NHSBT ‘conduct or commission such research within the field of organ donation and transplantation as NHSBT considers appropriate’ (3(1)(k)).
The merger of UKT with the National Blood Service (NBS) to form NHSBT has, amongst other consequences, allowed ODT access to some of the resources within the combined organisation. This resource has resulted in several initiatives, including access to NHSBT Research and Development (R&D) funding which has supported several studies and clinical fellows.
Currently, in the UK most research into the areas of organ donation and transplantation is undertaken by scientists and clinicians, largely working outside NHSBT and continues to be very successful at an international level. Transplant Units have developed their own programmes of research, often with funding from national and international bodies as well as industry. Most transplant units also have effective collaborations with more basic transplant-related research, primarily in University-supported laboratories.
Quality in Organ Donation
Currently, NHSBT R&D is funding the Quality in Organ Donation (QUOD) programme. The Principal Investigator is Professor Rutger Ploeg, Department of Surgery, University of Oxford. QUOD has developed a bioresource of well characterised material which will allow recipient outcomes to be traced and help researchers to improve the quality of donated organs it will also provide a focus for stimulating research further.